PXD083419-1

PXD083419 is an original dataset announced via ProteomeXchange.

Title	Pin Cervical cancer, IHA and HELA
Description	Cervical cancer, primarily driven by persistent high-risk human papillomavirus (HR-HPV) infection, remains a major global health burden. Cisplatin (CDDP), a first-line chemotherapeutic agent, faces limitations due to drug resistance and systemic toxicity. Phenanthriplatin (Phen-Pt), a monofunctional platinum derivative, exhibits a distinct antitumor profile and enhanced cellular uptake. This study evaluated the cytotoxic effects and mechanisms of Phen-Pt in normal cervical (ECT1/E6E7) and cervical cancer (SiHa/HeLa) cells. Proteomic analyses revealed that Phen-Pt modulates multiple biological processes, including metabolic pathways, apoptosis, immune responses, and extracellular matrix organization, with significant enrichment in cancer-related and viral infection pathways. Key genes involved in metabolism and apoptosis were differentially regulated, further supporting its multi-target mechanism.
HostingRepository	iProX
AnnounceDate	2026-08-29
AnnouncementXML	Submission_2026-09-01_17:46:27.527.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zuoping Li
SpeciesList	scientific name: Acyrthosiphon pisum; NCBI TaxID: 7029;
ModificationList	isotope labeled residue
Instrument	LTQ

Revision	Datetime	Status	ChangeLog Entry
0	2026-08-31 02:07:03	ID requested
⏵ 1	2026-09-01 17:46:28	announced

Dataset with its publication pending

submitter keyword: Cervical cancer, PIN, DNA damage, HPV E6/E7, Apoptosis

Zuoping Li
contact affiliation	Xinjiang University of Science&Technology
contact email	1667754715@QQ.COM
lab head
Zuoping Li
contact affiliation	Xinjiang University of Science&Technology
contact email	1667754715@qq.com
dataset submitter

iProX dataset URI