PXD083113-1

PXD083113 is an original dataset announced via ProteomeXchange.

Title	Proteomic quantification of vesicle samples from human cell lines
Description	To explore the specific alteration in host epithelial EVs induced by glucocorticoid, we performed liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based proteomic analysis on EVs derived from HOKs pretreated with glucocorticoid or not. The results showed a total of 389 differentially expressed proteins . Among the top 10 upregulated proteins, most were extracellular matrix (ECM) components ). Enrichment analysis of the relevant proteins revealed that the upregulated GO terms were centered on collagen binding, cell adhesion, and extracellular matrix component aggregation. Meanwhile, the associated biological processes included epithelial cell proliferation and differentiation, fibrin synthesis, regulation of epithelial healing, and barrier repair . The volcano plot revealed that, among the top ten most significantly upregulated proteins, two ECM proteins Lumican and Biglycan are closely related to barrier repair.
HostingRepository	iProX
AnnounceDate	2026-08-21
AnnouncementXML	Submission_2026-08-25_01:55:30.094.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xinyu Wang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF HT

Revision	Datetime	Status	ChangeLog Entry
0	2026-08-25 01:54:31	ID requested
⏵ 1	2026-08-25 01:55:30	announced

Dataset with its publication pending

submitter keyword: Extracellular vesicles, Glucocorticoid, Human Oral Keratinocytes, ECM proteins

Shiyu Liu
contact affiliation	The Fourth Military Medical University
contact email	liushiyu@fmmu.edu.cn
lab head
Xinyu Wang
contact affiliation	The Fourth Military Medical University
contact email	996116571@qq.com
dataset submitter

iProX dataset URI