PXD081684-1

PXD081684 is an original dataset announced via ProteomeXchange.

Title	Isoquercitrin alleviates subchronic high-altitude hypoxia-induced myocardial injury by regulating mitochondrial energy metabolism and maintaining immune–inflammatory homeostasis
Description	Echocardiography, blood gas analysis, myocardial histopathology, transmission electron microscopy, and integrative multiomics (RNA-seq, UPLC-MS/MS, and DDA-MS proteomics) were performed. Taken together, the results indicate that IQ mitigates subchronic high-altitude hypoxia-induced myocardial metabolic reprogramming and functional injury through multitarget synergistic regulation of the hematopoietic–immune–energy metabolic network, thus offering a novel therapeutic strategy for preventing and treating high-altitude heart disease.
HostingRepository	iProX
AnnounceDate	2026-07-27
AnnouncementXML	Submission_2026-07-27_01:02:13.097.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jiao Zhao
SpeciesList	scientific name: Rattus norvegicus; NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2026-07-27 01:01:55	ID requested
⏵ 1	2026-07-27 01:02:13	announced

Dataset with its publication pending

submitter keyword: Isoquercitrin

High-altitude hypoxia

Mitochondrial dysfunction

Glycolysis;

Xinxing Wang
contact affiliation	Military Medical Sciences Academy, Academy of Military Sciences
contact email	wxxemail@sina.cn
lab head
Jiao Zhao
contact affiliation	Military Medical Sciences Academy, Academy of Military Sciences
contact email	1256132920@qq.com
dataset submitter

iProX dataset URI