Echocardiography, blood gas analysis, myocardial histopathology, transmission electron microscopy, and integrative multiomics (RNA-seq, UPLC-MS/MS, and DDA-MS proteomics) were performed. Taken together, the results indicate that IQ mitigates subchronic high-altitude hypoxia-induced myocardial metabolic reprogramming and functional injury through multitarget synergistic regulation of the hematopoietic–immune–energy metabolic network, thus offering a novel therapeutic strategy for preventing and treating high-altitude heart disease.