⮝ Full datasets listing
PXD081026-1
PXD081026 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Targeting the MUC1-MAPK-Elk-1-PD-L1 Axis with γδ T Cell Membrane-Camouflaged GO-203 Nanoparticles Induces Apoptosis and Reverses Immunosuppression in Non-Small Cell Lung Cancer |
| Description | Non-small cell lung cancer (NSCLC) frequently resists apoptosis and immunotherapy due to MUC1 overexpression, which activates the MAPK-Elk-1-PD-L1 axis to promote immune evasion and suppress γδ T cell-mediated tumor killing. This study aimed to delineate this pathway and evaluate a biomimetic nanotherapeutic approach using γδ T cell membrane-camouflaged, MUC1-targeted nanoparticles loaded with GO-203 to induce tumor cell apoptosis and restore antitumor immunity. |
| HostingRepository | iProX |
| AnnounceDate | 2026-07-14 |
| AnnouncementXML | Submission_2026-07-14_00:35:17.082.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hongchuan Zhang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-07-14 00:34:58 | ID requested | |
| ⏵ 1 | 2026-07-14 00:35:17 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: MUC1 |
Contact List
| Zhao Yang | |
|---|---|
| contact affiliation | Dianjiang People’s Hospital of Chongqing |
| contact email | yangzhao5140@sohu.com |
| lab head | |
| Hongchuan Zhang | |
| contact affiliation | Dianjiang People’s Hospital of Chongqing |
| contact email | 1545559471@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
