PXD079738-1

PXD079738 is an original dataset announced via ProteomeXchange.

Title	4D-DIA proteomics analysis of lung tissues before and after intervention with honeysuckle polyphenols in mice with acute lung injury
Description	A total of 8,473 proteins were identified, with 1,558 proteins sub-jected to quantitative analysis. Using the above criteria of fold-change thresholds of 1.2 (upregulation) and 0.83 (downregulation), 328 differentially expressed proteins (DEPs) were identified , of which 156 were downregulated and 172 were upregulated. Additionally, GO and KEGG enrichment analyses were conducted to collectively characterize the 328 DEPs. The vast majority of GO biological process (BP) terms are related to inflammatory responses and oxidative stress, such as antigenic-induced acute inflammatory reaction, positive regula-tion of hydrogen peroxide catabolic process, and nitric oxide transport. Notably, the GO cellular component (CC) and molecular function (MF) categories highlighted key terms in-cluding hemoglobin interaction and Toll-like receptor 4 (TLR4) binding, both of which are implicated in inflammatory response and oxidative stress.
HostingRepository	iProX
AnnounceDate	2026-06-15
AnnouncementXML	Submission_2026-06-15_17:52:19.054.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yingjian Guo
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Ultra

Revision	Datetime	Status	ChangeLog Entry
0	2026-06-15 17:51:59	ID requested
⏵ 1	2026-06-15 17:52:19	announced

Dataset with its publication pending

submitter keyword: Lonicerae japonicae Flos

polyphenols

acute lung injury

Jinqian Yu
contact affiliation	Qilu University of Technology
contact email	yujinqian87528@162.com
lab head
Yingjian Guo
contact affiliation	Qilu University of Technology
contact email	guoyingjian111@163.com
dataset submitter

iProX dataset URI