PXD079349-1

PXD079349 is an original dataset announced via ProteomeXchange.

Title	Tau-P301L transgenic cynomolgus monkey cortex and spinal cord 4D label-free proteome dataset
Description	This dataset contains 4D-label-free quantitative proteomic profiles of cortex and spinal cord tissues from Tau P301L transgenic cynomolgus monkeys and wild-type controls. Sixteen tissue samples were analyzed, including wild-type cortex, wild-type spinal cord, Tau P301L cortex, and Tau P301L spinal cord, with four biological samples in each group. Peptides were measured on a Bruker timsTOF Pro mass spectrometer coupled to a nanoElute LC system using PASEF acquisition. Raw Bruker data were searched and quantified with MaxQuant 1.6.14 against the UniProt Macaca fascicularis protein database uniprot_Macaca_fascicularis_80185_20230915.fasta. The experiment identified 6,632 proteins and quantified 6,310 proteins, providing a tissue-resolved proteomic resource for the Tau P301L non-human-primate model.The deposited dataset includes raw Bruker .d files, MaxQuant search outputs and processed protein quantification matrices.
HostingRepository	PRIDE
AnnounceDate	2026-08-20
AnnouncementXML	Submission_2026-08-19_20:32:46.131.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Weien liang
SpeciesList	scientific name: Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey); NCBI TaxID: NEWT:9541;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Bruker Daltonics timsTOF series

Revision	Datetime	Status	ChangeLog Entry
0	2026-06-07 09:52:21	ID requested
⏵ 1	2026-08-19 20:32:46	announced

Dataset with its publication pending

submitter keyword: 4D proteomics, cortex, label-free quantification,Tauopathy, neurodegeneration, Macaca fascicularis, LC-MS/MS, spinal cord

Zhuchi Tu
contact affiliation	Guangdong Provincial Key Laboratory of Non-human Primate Research, Guangdong-Hong Kong-Macau Institute of CNS Regeneration, School of Medicine, Jinan University, Guangzhou, China
contact email	atuwater@163.com
lab head
Weien liang
contact affiliation	Jinan University
contact email	weliang@stu2024.jnu.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD079349

PRIDE project URI

• PRIDE
  1. PXD079349
     1. Label: PRIDE project
     2. Name: Tau-P301L transgenic cynomolgus monkey cortex and spinal cord 4D label-free proteome dataset