PXD076742-2

PXD076742 is an original dataset announced via ProteomeXchange.

Title	Spin-driven Enantioselective Regulation of Cyclooxygenase-2 Activity for Rheumatoid Arthritis Therapy via Chiral Gold Nanohelices
Description	Electron-spin dynamics represent an unexplored dimension in enzymatic catalysis, where most regulatory strategies focus on modulating active-site chemistry. Here, we present a spintronic approach that employs chiral gold nanohelices (CAu) as electron spin polarizers to enantiospecifically modulate cyclooxygenase-2 (COX-2) activity for rheumatoid arthritis intervention. Exploiting the chirality-induced spin selectivity (CISS) effect inherent to both COX-2 and CAu, we demonstrate that left-handed CAu (Lh-CAu) enhances, whereas right-handed CAu (Rh-CAu) suppresses COX-2 catalytic efficiency via spin-dependent electron transfer at the chiral nanoparticle-enzyme interfaces. To achieve targeted modulation in complex biological settings, we further engineering of molecularly imprinted CAu (CAu@MIP) for selectively regulating COX-2 in inflammatory cells and collagen-induced arthritis murine model. Treatment with Rh-CAu@MIP significantly reduces prostaglandin E₂ secretion and mitigates joint inflammation, achieving therapeutic efficacy comparable to conventional COX-2 inhibitors. Our findings introduce electron spin polarization as an orthogonal mechanism for enzymatic regulation, offering a bioelectronic strategy for inflammation-targeted therapy.
HostingRepository	iProX
AnnounceDate	2026-04-08
AnnouncementXML	Submission_2026-05-11_02:10:07.923.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jiao Yan
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Astral

Revision	Datetime	Status	ChangeLog Entry
0	2026-04-08 01:45:47	ID requested
1	2026-04-08 01:46:05	announced
⏵ 2	2026-05-11 02:10:09	announced	2026-05-11: Add info.

Yan J, Liu L, Chen Z, Zhao Q, Han X, Wang Y, Mu Z, Wang X, Song P, Kang Y, Lu W, Guo AM, Sun QF, Zhang H, Spin-driven enantioselective regulation of cyclooxygenase-2 activity for rheumatoid arthritis therapy via chiral gold nanohelices. Nat Commun, ():(2026) [pubmed]

submitter keyword: inflammation, COX-2, chiral nanoparticles, rheumatoid arthritis

Jiao Yan
contact affiliation	Guangzhou Medical University
contact email	yanjiao@gzhmu.edu.cn
lab head
Jiao Yan
contact affiliation	Guangzhou Medical University
contact email	yanjiao@gzhmu.edu.cn
dataset submitter

iProX dataset URI