PXD076742-1

PXD076742 is an original dataset announced via ProteomeXchange.

Title	Spin-driven Enantioselective Regulation of Cyclooxygenase-2 Activity for Rheumatoid Arthritis Therapy via Chiral Gold Nanohelices
Description	Electron-spin dynamics represent an unexplored dimension in enzymatic catalysis, where most regulatory strategies focus on modulating active-site chemistry. Here, we present a spintronic approach that employs chiral gold nanohelices (CAu) as electron spin polarizers to enantiospecifically modulate cyclooxygenase-2 (COX-2) activity for rheumatoid arthritis intervention. Exploiting the chirality-induced spin selectivity (CISS) effect inherent to both COX-2 and CAu, we demonstrate that left-handed CAu (Lh-CAu) enhances, whereas right-handed CAu (Rh-CAu) suppresses COX-2 catalytic efficiency via spin-dependent electron transfer at the chiral nanoparticle-enzyme interfaces. To achieve targeted modulation in complex biological settings, we further engineering of molecularly imprinted CAu (CAu@MIP) for selectively regulating COX-2 in inflammatory cells and collagen-induced arthritis murine model. Treatment with Rh-CAu@MIP significantly reduces prostaglandin E₂ secretion and mitigates joint inflammation, achieving therapeutic efficacy comparable to conventional COX-2 inhibitors. Our findings introduce electron spin polarization as an orthogonal mechanism for enzymatic regulation, offering a bioelectronic strategy for inflammation-targeted therapy.
HostingRepository	iProX
AnnounceDate	2026-04-08
AnnouncementXML	Submission_2026-04-08_01:46:04.808.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jiao Yan
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Astral

Revision	Datetime	Status	ChangeLog Entry
0	2026-04-08 01:45:47	ID requested
⏵ 1	2026-04-08 01:46:05	announced

Dataset with its publication pending

submitter keyword: inflammation, COX-2, chiral nanoparticles, rheumatoid arthritis

Jiao Yan
contact affiliation	Guangzhou Medical University
contact email	yanjiao@gzhmu.edu.cn
lab head
Jiao Yan
contact affiliation	Guangzhou Medical University
contact email	yanjiao@gzhmu.edu.cn
dataset submitter

iProX dataset URI