PXD075840-2

PXD075840 is an original dataset announced via ProteomeXchange.

Title	Biomarker Prediction for Lung Cancer Chemoradiotherapy Efficacy Based on Proteomics
Description	The response of lung cancer to chemoradiotherapy (CRT) is orchestrated by the dynamic interplay between immune microenvironment remodeling and metabolic reprogramming. However, robust biomarkers for predicting patient prognosis remain elusive. In this study, we performed proteomics profiling of 22 pairs of lung cancer specimens and compared CRT-sensitive versus CRT-resistant subtypes. Functional analysis revealed distinct pathway enrichment between the two groups: the CRT-sensitive subtype was predominantly associated with fatty acid oxidation and energy metabolism, whereas the CRT-resistant subtype exhibited elevated immune activation, inflammatory responses, and stress-related signaling. Based on these findings, we developed a LASSO regression-based predictive model that pinpointed a protein signature encompassing IKBKB interacting protein (IKBIP) and citron rho-interacting serine/threonine kinase (CIT) as optimal predictors of CRT efficacy. Subsequent survival analysis further confirmed the prognostic relevance of these proteins. Collectively, our findings emphasize the critical role of the metabolic-immune axis in modulating CRT sensitivity and provide mechanistic insights into the molecular underpinnings of treatment response, thereby offering a clinically translatable tool for guiding precision therapeutic strategies in lung cancer.
HostingRepository	iProX
AnnounceDate	2026-03-19
AnnouncementXML	Submission_2026-06-04_01:30:54.723.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xinbo Wang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2026-03-19 00:44:30	ID requested
1	2026-05-28 02:46:45	announced
⏵ 2	2026-06-04 01:30:55	announced	2026-06-04: Add info

Ouyang W, Wang Y, Yang J, Cao D, Wang Q, Luo Y, Tian C, Huang H, Wang X, Comprehensive Proteomic Profiling Reveals Molecular Mechanisms Mediating Chemoradiotherapy Efficacy in Lung Cancer. J Proteome Res, ():(2026) [pubmed]

submitter keyword: Lung cancer, Chemoradiotherapy efficacy, Proteomics, Biomarker

He Huang
contact affiliation	State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
contact email	hhuang@simm.ac.cn
lab head
Xinbo Wang
contact affiliation	State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
contact email	wangxinbo@simm.ac.cn
dataset submitter

iProX dataset URI