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PXD075840-1
PXD075840 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Biomarker Prediction for Lung Cancer Chemoradiotherapy Efficacy Based on Proteomics |
| Description | The response of lung cancer to chemoradiotherapy (CRT) is orchestrated by the dynamic interplay between immune microenvironment remodeling and metabolic reprogramming. However, robust biomarkers for predicting patient prognosis remain elusive. In this study, we performed proteomics profiling of 22 pairs of lung cancer specimens and compared CRT-sensitive versus CRT-resistant subtypes. Functional analysis revealed distinct pathway enrichment between the two groups: the CRT-sensitive subtype was predominantly associated with fatty acid oxidation and energy metabolism, whereas the CRT-resistant subtype exhibited elevated immune activation, inflammatory responses, and stress-related signaling. Based on these findings, we developed a LASSO regression-based predictive model that pinpointed a protein signature encompassing IKBKB interacting protein (IKBIP) and citron rho-interacting serine/threonine kinase (CIT) as optimal predictors of CRT efficacy. Subsequent survival analysis further confirmed the prognostic relevance of these proteins. Collectively, our findings emphasize the critical role of the metabolic-immune axis in modulating CRT sensitivity and provide mechanistic insights into the molecular underpinnings of treatment response, thereby offering a clinically translatable tool for guiding precision therapeutic strategies in lung cancer. |
| HostingRepository | iProX |
| AnnounceDate | 2026-03-19 |
| AnnouncementXML | Submission_2026-05-28_02:46:45.023.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xinbo Wang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-03-19 00:44:30 | ID requested | |
| ⏵ 1 | 2026-05-28 02:46:45 | announced | |
| 2 | 2026-06-04 01:30:55 | announced | 2026-06-04: Add info |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Lung cancer, Chemoradiotherapy efficacy, Proteomics, Biomarker |
Contact List
| He Huang | |
|---|---|
| contact affiliation | State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences |
| contact email | hhuang@simm.ac.cn |
| lab head | |
| Xinbo Wang | |
| contact affiliation | State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences |
| contact email | wangxinbo@simm.ac.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
