PXD074799-1

PXD074799 is an original dataset announced via ProteomeXchange.

Title	Multimodal Antidepressant Actions of Schisanhenol Through 5-LOX Modulation, Neuroinflammation Suppression, and Synaptic Repair
Description	This project focuses on the core research direction of \"Wuweizi phenol exerting multimodal antidepressant effects by regulating 5-lipoxygenase (5-LOX), inhibiting neuroinflammation, and repairing synaptic function\". It employs quantitative proteomics technology based on liquid chromatography-tandem mass spectrometry (LC-MS/MS), using a mouse model of depression-like behavior induced by chronic social defeat stress (Chronic Social Defeat Stress, CSDS) as the research object. The project systematically analyzes the differences in protein expression profiles in the prefrontal cortex (Prefrontal Cortex, PFC) of mice in the model group, normal control group, and Wuweizi phenol intervention group. The core goal is to screen key differentially expressed proteins (Differentially Expressed Proteins, DEPs) associated with CSDS-induced depression-like behaviors, 5-LOX signaling pathway regulation, neuroinflammation, and synaptic damage/repair. It aims to deeply explore the core signaling pathways and molecular regulatory networks involved in DEPs, clarify the protein-level mechanism by which Wuweizi phenol exerts antidepressant effects, and simultaneously provide solid proteomic data support and scientific theoretical basis for elucidating the pathogenesis of depression, screening potential diagnostic markers, and developing antidepressant drugs targeting 5-LOX regulation, neuroinflammation inhibition, or synaptic repair.
HostingRepository	iProX
AnnounceDate	2026-02-12
AnnouncementXML	Submission_2026-02-24_16:43:15.724.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yi Zhang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2026-02-24 16:42:52	ID requested
⏵ 1	2026-02-24 16:43:16	announced

Dataset with its publication pending

submitter keyword: csds, Neuroinflammation, Synaptic Repair

Jing Du
contact affiliation	Capital Medical University
contact email	dujing2020@ccmu.edu.cn
lab head
Yi Zhang
contact affiliation	Capital Medical University
contact email	zhangyi19930423@163.com
dataset submitter

iProX dataset URI