PXD074138 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic Profiling of the 5‑HT2B Receptor Agonist BW723C86 on Migration and Signaling in Mouse Bone Marrow‑Derived Macrophages |
| Description | Mouse Bone marrow-derived macrophages (BMDMs) and HT22 neuronal cells (subjected to 2-hour oxygen-glucose deprivation, OGD-2h) were used in this study. To investigate cell migration, a Transwell assay was performed. For pharmacological intervention, cells were treated with either the serotonin receptor 2B (5-HT2B) agonist BW723C86 or dimethyl sulfoxide (DMSO) as a vehicle control. Following treatment, global protein expression profiling was performed using mass spectrometry-based quantitative proteomics. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-07-04 |
| AnnouncementXML | Submission_2026-07-04_07:35:52.908.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | yonghui chen |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-02-06 01:46:12 | ID requested | |
| ⏵ 1 | 2026-07-04 07:35:53 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Mouse bone marrow‑derived macrophages (BMDMs)，5‑HT2B receptor，BW723C86，Transwell assay，LC-MSMS |
Contact List
| yueman Zhang |
|---|
| contact affiliation | Department of Anesthesiology, Clinical Research Center, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China |
| contact email | altas_zhang@163.com |
| lab head | |
| yonghui chen |
|---|
| contact affiliation | Renji Hospital, Shanghai Jiao Tong University School of Medicine |
| contact email | cyhgordon@163.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD074138 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD074138
- Label: PRIDE project
- Name: Proteomic Profiling of the 5‑HT2B Receptor Agonist BW723C86 on Migration and Signaling in Mouse Bone Marrow‑Derived Macrophages
