PXD074030-1

PXD074030 is an original dataset announced via ProteomeXchange.

Title	Determination of autophosphorylation sites of human HRI
Description	This dataset assesses the effects of DELE1 on Succinylacetone (SA)- and dihydroartemisinin (DHA)-induced auto-phosphorylation of endogenous human HRI, as well as the heme-dependent repression of HRI auto-phosphorylation. This dataset identifies DELE1-induced phosphorylation sites in the second kinase domain and the kinase insert and phosphorylation sites in the second kinase domain and the kinase insert that are repressed by hemin.
HostingRepository	PanoramaPublic
AnnounceDate	2026-05-06
AnnouncementXML	Submission_2026-05-06_12:48:53.976.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Julia Mergner
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	Phospho; Carbamidomethyl
Instrument	Orbitrap Eclipse

Revision	Datetime	Status	ChangeLog Entry
0	2026-02-03 22:55:20	ID requested
⏵ 1	2026-05-06 12:48:54	announced

no publication

submitter keyword: DELE1, EIF2AK1, HRI, Heme, Mitochondria

Julia Mergner
contact affiliation	Bavarian Center for Biomolecular Mass Spectrometry at Klinikum rechts der Isar (BayBioMS@MRI), TUM School of Medicine and Health, Technical University of Munich (TUM), 81675 München, Germany
contact email	julia.mergner@tum.de
lab head
Julia Mergner
contact affiliation	Bavarian Center for Biomolecular Mass Spectrometry at Klinikum rechts der Isar (BayBioMS@MRI), TUM School of Medicine and Health, Technical University of Munich (TUM), 81675 München, Germany
contact email	julia.mergner@tum.de
dataset submitter

Panorama Public dataset URI