PXD072912-1

PXD072912 is an original dataset announced via ProteomeXchange.

Title	Mitochondria-related gene and protein changes in craniosynostosis: integrated transcriptomics and Fgfr2C361Y/+ cranial suture proteomics
Description	This project maps mitochondria-associated molecular changes in craniosynostosis by integrating public human transcriptomes and by generating proteomic data from a genetically defined mouse model. Differential expression signals were intersected with the MitoCarta 3.0 inventory to prioritize mitochondrial candidates, and cranial suture tissue from Fgfr2C361Y/+ knock-in mice and wild-type littermates was profiled to provide protein-level support.
HostingRepository	iProX
AnnounceDate	2026-01-09
AnnouncementXML	Submission_2026-01-11_23:05:44.525.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Han Zeng
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2026-01-11 23:05:19	ID requested
⏵ 1	2026-01-11 23:05:45	announced

Dataset with its publication pending

submitter keyword: craniosynostosis, mitochondria, FGFR2, Fgfr2C361Y/+, cranial suture, DIA proteomics, diaPASEF, timsTOF HT, transcriptomics, MitoCarta

XiaoLei Jin
contact affiliation	Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
contact email	zxyy16jxl@163.com
lab head
Han Zeng
contact affiliation	Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
contact email	m13371606297@163.com
dataset submitter

iProX dataset URI