This project maps mitochondria-associated molecular changes in craniosynostosis by integrating public human transcriptomes and by generating proteomic data from a genetically defined mouse model. Differential expression signals were intersected with the MitoCarta 3.0 inventory to prioritize mitochondrial candidates, and cranial suture tissue from Fgfr2C361Y/+ knock-in mice and wild-type littermates was profiled to provide protein-level support.