PXD072837 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Bioprinted 3D vascularized human placenta models recapitulate early and late stages of pregnancy |
| Description | The placenta is a highly dynamic organ that supports the growth and development of the fetus throughout the different stages of pregnancy. Malfunction of the placenta causes disorders of the pregnancy, including preeclampsia and pre-term birth. The study of the pathophysiology of the placenta at different stages of pregnancy has been hindered by limited access to the human placenta and lack of predictive cellular and animal models. Here, we describe 3D bioprinted vascularized human placenta barrier (hPB) tissue models using primary human trophoblasts and stroma cells that recapitulate the physiology of the human placenta at early and late stages of gestation. These bioprinted vascularized hPB tissue models mimic the architecture and function of late and early-stages human placenta, including barrier function, nutrient uptake, transporters activity and hormones secretion. These vascularized hPB models were assembled in a 96-well microplate format to enable robust drug screening for placenta diseases and safety. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-09-07 |
| AnnouncementXML | Submission_2026-09-07_04:32:58.726.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Dingyin Tao |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-01-08 19:14:21 | ID requested | |
| ⏵ 1 | 2026-09-07 04:32:59 | announced | |
Publication List
| 10.1038/s41598-026-61708-y; |
| Antich C, Chen YC, Noel J, Qu Y, Fang Y, Frebert S, Tao D, Richardson LS, Menon R, Song MJ, Ferrer M, Recapitulating gestational progression: a high-throughput 3D bioprinted vascularized human placenta demonstrating stage-specific molecular and functional signatures of human pregnancy. Sci Rep, 16(1):(2026) [pubmed] |
Keyword List
| submitter keyword: LC-MSMS,human, placenta 3D model |
Contact List
| Dingyin Tao |
|---|
| contact affiliation | National Center for Advancing Translational Sciences, National Institutes of Health |
| contact email | dingyin.tao@nih.gov |
| lab head | |
| Dingyin Tao |
|---|
| contact affiliation | National Institutes of Health (NIH)
National Center for Advancing Translational Sciences (NCATS) |
| contact email | dingyin.tao@nih.gov |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD072837
- Label: PRIDE project
- Name: Bioprinted 3D vascularized human placenta models recapitulate early and late stages of pregnancy
