PXD072759 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | MARCH2 prevents doxorubicin-induced cardiomyopathy by stabilizing NR1H2 and promoting clearance of apoptotic cardiomyocytes |
| Description | Doxorubicin-induced cardiomyopathy (DiCM) is a leading cause of heart failure and mortality in cancer patients, with doxorubicin-induced cardiomyocyte apoptosis constituting a fundamental pathological mechanism. Cardiac resident macrophages are primarily responsible for the effective clearance of apoptotic cardiomyocytes (efferocytosis), a process pivotal for suppressing inflammatory response and adverse cardiac remodeling. To identify genes implicated in DiCM, RNA sequencing was performed using heart tissues from saline- and DOX-treated wild-type (WT) mice. Ubiquitin mass spectrometry was used to identify the ubiquitin site of nuclear receptor subfamily 1 group H member 2 (NR1H2). |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-15 |
| AnnouncementXML | Submission_2026-06-14_16:10:32.525.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | shuolin liu |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | ubiquitinylated lysine; phosphorylated residue |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2026-01-07 09:58:09 | ID requested | |
| ⏵ 1 | 2026-06-14 16:10:33 | announced | |
Publication List
| 10.1038/s41467-026-71580-z; |
| Liu S, Li YE, Zhu T, Zhang L, Yang C, Bi Y, Bao C, Hu R, Ge J, Zhang Y, MARCH2 prevents doxorubicin-induced cardiomyopathy by stabilizing NR1H2 and promoting clearance of apoptotic cardiomyocytes. Nat Commun, 17(1):(2026) [pubmed] |
Keyword List
| submitter keyword: anthracyclines |
| macrophage |
| MARCH2 |
| heart failure |
| mice |
Contact List
| Shuolin Liu |
|---|
| contact affiliation | 1 Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, China. 2 Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. |
| contact email | liushuolin007@163.com |
| lab head | |
| shuolin liu |
|---|
| contact affiliation | Department of Cardiology and Shanghai Institute of Cardiovascular Diseases
Zhongshan Hospital, Fudan University |
| contact email | liushuolin007@163.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD072759 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD072759
- Label: PRIDE project
- Name: MARCH2 prevents doxorubicin-induced cardiomyopathy by stabilizing NR1H2 and promoting clearance of apoptotic cardiomyocytes
