PXD071963-1

PXD071963 is an original dataset announced via ProteomeXchange.

Title	Proteomic Insights into Moxifloxacin Efficacy and Resistance in Vibrio parahaemolyticus
Description	This project provides a quantitative proteomic dataset investigating the direct antibacterial effect of moxifloxacin on the foodborne pathogen Vibrio parahaemolyticus. Using liquid chromatography-tandem mass spectrometry (LC-MS/MS), we systematically compared the global protein expression profiles of bacterial cells exposed to a sub-inhibitory concentration of moxifloxacin against an untreated control. The data captures the dynamic proteomic response, revealing differentially expressed proteins involved in critical pathways such as DNA replication, oxidative stress defense, and cell envelope homeostasis. This resource is valuable for elucidating the mechanism of action of fluoroquinolones and understanding the early adaptive responses of V. parahaemolyticus to antibiotic stress, serving as a foundation for research into antimicrobial efficacy and resistance prevention.
HostingRepository	iProX
AnnounceDate	2025-12-11
AnnouncementXML	Submission_2025-12-13_23:14:59.846.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Huaiyao Zhang
SpeciesList	scientific name: Vibrio parahaemolyticus S052; NCBI TaxID: 1394597;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 240

Revision	Datetime	Status	ChangeLog Entry
0	2025-12-13 23:14:46	ID requested
⏵ 1	2025-12-13 23:15:00	announced

Dataset with its publication pending

submitter keyword: Vibrio parahaemolyticus, Antibiotic resistance, Moxifloxacin, Proteomics

Xiangmin Lin
contact affiliation	Fujian Agriculture and Forestry University
contact email	313461278@qq.com
lab head
Huaiyao Zhang
contact affiliation	Fujian Agriculture and Forestry University
contact email	458842484@qq.com
dataset submitter

iProX dataset URI