PXD071500 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Identification of Microproteins in AD Using DIA Mass Spectrometry |
| Description | Alzheimer’s disease (AD) is defined by abnormal protein accumulation and broad disruptions in proteostasis, yet most proteomic studies focus solely on annotated proteins. Microproteins are largely excluded because they are missing from standard reference databases. To address this gap, we performed data-independent acquisition (DIA) proteomics on dorsolateral prefrontal cortex (DLPFC) tissue from a small pilot cohort (n = 2 AD, n = 2 control; all male; average age 82.5 years). This approach was chosen to sensitively capture low-abundance peptides that are typically missed by DDA workflows. Across these samples, we identified more than 100 microproteins that were absent from previous large-scale DDA-based datasets. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-09-09 |
| AnnouncementXML | Submission_2026-09-09_12:21:15.910.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Brendan Miller |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-12-02 18:23:20 | ID requested | |
| ⏵ 1 | 2026-09-09 12:21:16 | announced | |
Publication List
Keyword List
| submitter keyword: Brain, microproteins, DIA |
Contact List
| Alan Saghatelian |
|---|
| contact affiliation | Salk Institute for Biological Studies |
| contact email | asaghatelian@salk.edu |
| lab head | |
| Brendan Miller |
|---|
| contact affiliation | Salk Institute |
| contact email | brmiller@salk.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD071500 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD071500
- Label: PRIDE project
- Name: Identification of Microproteins in AD Using DIA Mass Spectrometry
