PXD071248-1

PXD071248 is an original dataset announced via ProteomeXchange.

Title	Identification of Putative Kidney-Derived Proteins in Plasma using Nanoparticle Enrichment
Description	Many diseases, including diabetes and hypertension, can lead to kidney damage, often resulting in long-term health complications and organ failure. Both animal and human studies have documented a causal relationship between high dietary sodium intake and elevated blood pressure. We explored a proteomics analysis of plasma samples to detect early kidney damage in response to a high sodium (HS) diet through the quantification of putative kidney-derived proteins in plasma for early disease detection. Plasma samples from 7 female baboons fed a high sodium diet for 6 weeks were collected before and after the HS diet challenge. Plasma samples were analyzed using a novel nanoparticle enrichment protocol.
HostingRepository	PRIDE
AnnounceDate	2026-03-30
AnnouncementXML	Submission_2026-03-29_17:22:17.857.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Daniela Key
SpeciesList	scientific name: Papio hamadryas; NCBI TaxID: NEWT:9557;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-11-25 21:07:07	ID requested
⏵ 1	2026-03-29 17:22:18	announced

10.1093/molecular-omics/aaiag008;

Key Planas DA, Nazli S, Riojas AM, Reyes AC, Jadhav A, Zimmerman K, Cox LA, Olivier M, Identification of putative kidney-derived proteins in plasma using nanoparticle enrichment. Mol Omics, 22(2):(2026) [pubmed]

submitter keyword: LC-MSMS,Plasma, Tissue-leakage proteins, Diet challenge, Kidney, Baboon, Non-human primates, Sodium, Nanoparticle affinity enrichment

Michael Olivier
contact affiliation	Center for Precision Medicine at Wake Forest University School of Medicine
contact email	Michael.Olivier@wfusm.edu
lab head
Daniela Key
contact affiliation	Wake Forest University School of Medicine
contact email	daniela.keyplanas@wfusm.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD071248
     1. Label: PRIDE project
     2. Name: Identification of Putative Kidney-Derived Proteins in Plasma using Nanoparticle Enrichment