PXD069737-1

PXD069737 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	The Calmodulin/Striatin Interaction is Enhanced in Diabetic Hearts and Defines Novel Signaling Clusters implicated in Cardiac Remodeling
Description	Diabetic cardiomyopathy (DbCM) halts cardiac performance with a complex etiology, hence the absence of an effective therapy for this disease. Herein we decoded the proteins hub interconnected with Calmodulin (CaM), a striatin (STRN) binding protein, that plays a role in DbCM. Using CaM as a bait, we precipitated protein clusters from left ventricles (LVs) of diabetic hearts at two stages of diabetes; 8- and 24-weeks rats treated with streptozotocin-STZ. Diabetic rats showed pathological heart remodeling confirmed by increased heart/body weight (HW/BW) ratio and increased β-MHC protein levels and ANF mRNA expression.
HostingRepository	PRIDE
AnnounceDate	2026-06-15
AnnouncementXML	Submission_2026-06-14_16:38:41.384.xml
DigitalObjectIdentifier	https://doi.org/10.6019/PXD069737
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Liaqat Ali
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: NEWT:10116;
ModificationList	phosphorylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-10-21 12:20:53	ID requested
⏵ 1	2026-06-14 16:38:42	announced

Publication List

10.6019/PXD069737;
Chacar S, Al Hageh C, Ali L, Zalloua P, Suleiman MS, Howarth FC, Khraibi AA, Nader M, The Calmodulin/Striatin Interaction Is Enhanced in Diabetic Hearts and Defines Novel Signaling Clusters Implicated in Cardiac Remodeling. ACS Omega, 11(21):30801-30811(2026) [pubmed]
10.1021/acsomega.5c13122;

10.6019/PXD069737;

Chacar S, Al Hageh C, Ali L, Zalloua P, Suleiman MS, Howarth FC, Khraibi AA, Nader M, The Calmodulin/Striatin Interaction Is Enhanced in Diabetic Hearts and Defines Novel Signaling Clusters Implicated in Cardiac Remodeling. ACS Omega, 11(21):30801-30811(2026) [pubmed]

10.1021/acsomega.5c13122;

Keyword List

submitter keyword: LC-MSMS,Rat, TMT, Cardiac Left Ventricles

submitter keyword: LC-MSMS,Rat, TMT, Cardiac Left Ventricles

Contact List

Moni Nader
contact affiliation	Department of Medical Sciences, College of Medicine and Health Sciences, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates and/or Department of Physiological Sciences, College of Medicine, Alfaisal University, Riyadh, Kingdom of Saudi Arabia.
contact email	mnader@alfaisal.edu
lab head
Liaqat Ali
contact affiliation	New York University Abu Dhabi
contact email	la77@nyu.edu
dataset submitter

Full Dataset Link List

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PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD069737

PRIDE project URI

Repository Record List

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