PXD069668-1

PXD069668 is an original dataset announced via ProteomeXchange.

Title	Protein misfolding exposes buried ubiquitination sites that drive rapid proteasomal clearance
Description	In this study, we combine structural proteomics and time-resolved isotopic labeling to profile the modification sites, dynamics, and conformational properties of the human ubiquitinome.
HostingRepository	PRIDE
AnnounceDate	2026-04-27
AnnouncementXML	Submission_2026-04-27_14:21:00.348.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Anushka Jain
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	6x(13)C labeled L-lysine; L-methionine sulfoxide; 6x(13)C; ubiquitination signature dipeptidyl lysine; 6x(13)C labeled L-arginine
Instrument	Orbitrap Astral

Revision	Datetime	Status	ChangeLog Entry
0	2025-10-20 07:41:01	ID requested
⏵ 1	2026-04-27 14:21:00	announced

Dataset with its publication pending

submitter keyword: None

Sina Ghaemmaghami
contact affiliation	Ghaemmaghami Lab, Department of Biology, University of Rochester, NY, US
contact email	sina.ghaemmaghami@rochester.edu
lab head
Anushka Jain
contact affiliation	University of Rochester
contact email	anushka.jain@rochester.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD069668

PRIDE project URI

• PRIDE
  1. PXD069668
     1. Label: PRIDE project
     2. Name: Protein misfolding exposes buried ubiquitination sites that drive rapid proteasomal clearance