PXD068298-1
PXD068298 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Mouse Testis IP-MS Analysis of FBXO24 Interacting Protein |
| Description | Through immunoprecipitation–mass spectrometry of FBXO24, we identified histone H1 variants, TNP2, and pre-PRM2 as specifically enriched interactors, highlighting a tight link between FBXO24 and the spermiogenic chromatin-remodeling axis. Using Fbxo24^R387X/R387X^ mice, we demonstrated that FBXO24 promotes the timely clearance of H1 and TNP2 and modulates pre-PRM2 nuclear distribution, thereby facilitating PRM2 maturation and sperm chromatin condensation. |
| HostingRepository | iProX |
| AnnounceDate | 2025-09-11 |
| AnnouncementXML | Submission_2025-09-11_17:23:53.467.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xin Wang |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-09-11 17:23:28 | ID requested | |
| ⏵ 1 | 2025-09-11 17:23:53 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Mouse, Testis, IP-MS |
Contact List
| Mingxi Liu | |
|---|---|
| contact affiliation | Nanjing Medical University |
| contact email | mingxi.liu@njmu.edu.cn |
| lab head | |
| Xin Wang | |
| contact affiliation | Nanjing Medical University |
| contact email | 1830220174@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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