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PXD065360-1

PXD065360 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic profiles of different subtypes of M2 macrophages
Description	Bone marrow-derived macrophages (BMDMs) were isolated from C57BL/6 mice and differentiated under standard culture conditions. Upon completion of differentiation, cells were subjected to cytokine stimulation to induce distinct M2 macrophage phenotypes. Specifically, M0 macrophages were polarized into M2a macrophages with 20 ng/mL interleukin-4 (IL-4), into M2b macrophages with 100 ng/mL lipopolysaccharide (LPS) in combination with 50 μg/mL mouse immunoglobulin G (IgG), and into M2c macrophages with 40 ng/mL interleukin-10 (IL-10). Following induction, the functional heterogeneity of M0, M2a, M2b and M2c macrophages was systematically assessed through proteomic profiling. The resulting data revealed distinct protein expression patterns reflective of the specialized functional roles of each macrophage subtype.
HostingRepository	iProX
AnnounceDate	2025-06-23
AnnouncementXML	Submission_2025-08-24_20:39:43.370.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Buayishamu Kutilike
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-23 19:47:43	ID requested
⏵ 1	2025-08-24 20:39:43	announced

Publication List

Dataset with its publication pending

Keyword List

submitter keyword: macrophages, M2 subtypes

Contact List

Xinglu Huang
contact affiliation	Nankai University
contact email	huangxinglu@nankai.edu.cn
lab head
Buayishamu Kutilike
contact affiliation	Nankai University
contact email	ayishaa11@163.com
dataset submitter

Full Dataset Link List

iProX dataset URI