PXD064802-1

PXD064802 is an original dataset announced via ProteomeXchange.

Title	miR-214-3p inhibits SiO₂-induced macrophage inflammation and attenuates pulmonary fibrosis by targeting Bim in silicosis
Description	Silicosis is a devastating occupational lung disease characterized by chronic inflammation and diffuse interstitial fibrosis. Previous studies have shown that miRNA imbalance contributes to silicosis progression, however, the role of miR-214-3p in silicosis is largely unknown. In this study, we performed proteomics analysis of macrophage transfected with miR-NC or miR-214-3p after silica dust exposure for 36 hours, to analyze the effect of miR-214-3p overexpression on SiO2-induced macrophage inflammation.
HostingRepository	iProX
AnnounceDate	2025-06-10
AnnouncementXML	Submission_2025-06-09_23:38:31.381.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yongbin Hu
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-09 23:38:14	ID requested
⏵ 1	2025-06-09 23:38:31	announced

Dataset with its publication pending

submitter keyword: Silicosis, SiO₂, macrophage, miR-214-3p, inflammation

Yongbin Hu
contact affiliation	Central South University
contact email	yongbinhu@csu.edu.cn
lab head
Yongbin Hu
contact affiliation	Central South University
contact email	yongbinhu@csu.edu.cn
dataset submitter

iProX dataset URI