PXD064520 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Identification of binding partners of the purified TOM complex from HEK293T cells |
| Description | To investigate the interactome of the human translocase of the outer mitochondrial membrane (TOM) complex, we performed immunoaffinity purification of TOMM22-FLAG from HEK293T cells followed by LC-MS/MS analysis. This approach allowed us to identify proteins that co-purify with the TOM complex under native conditions. Our primary aim was to uncover human-specific interactors not previously described in yeast, with a particular focus on factors potentially involved in mitochondrial protein import regulation and quality control. The dataset provides a resource for understanding conserved and divergent aspects of TOM complex composition and function in human cells. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-03-17 |
| AnnouncementXML | Submission_2026-03-17_08:25:20.525.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Remigiusz Serwa |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | acetylated residue; monohydroxylated residue; deaminated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-06-02 09:31:38 | ID requested | |
| ⏵ 1 | 2026-03-17 08:25:21 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: TOM complex, TOMM22-FLAG IP, HEK293T |
Contact List
| Agnieszka Chacinska |
|---|
| contact affiliation | IMol Polish Academy of Sciences, Warsaw, Poland |
| contact email | a.chacinska@imol.institute |
| lab head | |
| Remigiusz Serwa |
|---|
| contact affiliation | The International Institute of Molecular Mechanisms and Machines, Polish Academy of Sciences |
| contact email | r.serwa@imol.edu.pl |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD064520 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD064520
- Label: PRIDE project
- Name: Identification of binding partners of the purified TOM complex from HEK293T cells
