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PXD063361-1

PXD063361 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	synNotch CAR-Macrophages promote persistent antitumour activity through enhanced adaptive immunity
Description	Uploaded proteomics data provides a comprehensive snapshot of the protein expression profiles associated with macrophage polarization. In our study, the analysis focused on the conversion of M2 macrophages, which typically support tumor growth through immunosuppressive signals, into M1 macrophages known for their pro-inflammatory, tumoricidal activity. The data reveal a marked upregulation of key M1-associated proteins—such as those involved in NF-κB signaling and pro-inflammatory cytokine production—alongside a concurrent downregulation of M2-specific markers. This proteomic shift confirms the reprogramming of the macrophage phenotype and underscores the potential of targeting these molecular pathways as a novel anti-tumor strategy.
HostingRepository	iProX
AnnounceDate	2025-04-25
AnnouncementXML	Submission_2025-04-26_19:22:10.440.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jiayi Chen
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Astral

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-26 19:21:58	ID requested
⏵ 1	2025-04-26 19:22:11	announced

Publication List

Dataset with its publication pending

Keyword List

submitter keyword: macrophage, polarization

Contact List

Jiayi Chen
contact affiliation	Jilin University
contact email	jychen23@mails.jlu.edu.cn
lab head
Jiayi Chen
contact affiliation	Jilin University
contact email	jychen23@mails.jlu.edu.cn
dataset submitter

Full Dataset Link List

iProX dataset URI