Uploaded proteomics data provides a comprehensive snapshot of the protein expression profiles associated with macrophage polarization. In our study, the analysis focused on the conversion of M2 macrophages, which typically support tumor growth through immunosuppressive signals, into M1 macrophages known for their pro-inflammatory, tumoricidal activity. The data reveal a marked upregulation of key M1-associated proteins—such as those involved in NF-κB signaling and pro-inflammatory cytokine production—alongside a concurrent downregulation of M2-specific markers. This proteomic shift confirms the reprogramming of the macrophage phenotype and underscores the potential of targeting these molecular pathways as a novel anti-tumor strategy.