PXD063340 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Time resolved DIA MS analysis of FZO1 depletion in s. cerevisiae |
| Description | Mitochondrial biogenesis and inheritance must be carefully regulated alongside cell division to ensure proper mitochondrial function and cell survival. The dynamics of the mitochondrial network, including fusion and fission, play a crucial role in mitochondrial inheritance by facilitating the distribution and quality control of mitochondria. Here, we investigate the consequences of impaired mitochondrial fusion through depletion of Fzo1, which is essential for mitochondrial outer membrane fusion in s. cerevisiae. We use the AID (auxin-induced degron) system, which enables induced protein degradation and monitor changes in the proteome up to 21 hours after depletion. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-03-27 |
| AnnouncementXML | Submission_2026-03-27_09:22:08.436.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Bianca Lemke |
| SpeciesList | scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: NEWT:4932; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-04-25 08:04:00 | ID requested | |
| ⏵ 1 | 2026-03-27 09:22:08 | announced | |
Publication List
Keyword List
| submitter keyword: Yeast, DIA, Spectronaut, FZO1 depletion, LC-MS/MS |
Contact List
| Jennifer C. Ewald |
|---|
| contact affiliation | 1Molecular Cell Biology, Institute of Cell Biology, University of Tübingen |
| contact email | jennifer-christina.ewald@uni-tuebingen.de |
| lab head | |
| Bianca Lemke |
|---|
| contact affiliation | University of Tuebingen |
| contact email | bianca.lemke@uni-tuebingen.de |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD063340
- Label: PRIDE project
- Name: Time resolved DIA MS analysis of FZO1 depletion in s. cerevisiae
