PXD063140-1

PXD063140 is an original dataset announced via ProteomeXchange.

Title	Global chromatin-associated O-GlcNAc proteins are biased to oncogene-induced senescence (OIS) in human primary fibroblasts
Description	O-linked β-N-acetylglucosamine (O-GlcNAc) modification, a posttranslational modification (PTM) enriched in the nucleus and cytoplasm, is acknowledged to substantially contribute to the regulation of chromatin assembly and gene expression. studies have indicated that O-GlcNAc modification plays an important role in the process of cellular senescence. To integratively illustrate the regulatory role of O-GlcNAc modification in the oncogene-induced senescence (OIS) process, we employed a chemical reporter-based multi-omics strategy for a time-series proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins (OCPs) in human primary fibroblasts
HostingRepository	iProX
AnnounceDate	2025-04-20
AnnouncementXML	Submission_2025-04-20_22:24:13.266.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yubo Liu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro; Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-20 22:23:55	ID requested
⏵ 1	2025-04-20 22:24:13	announced

Dataset with its publication pending

submitter keyword: O-GlcNAc, metabolic labeling, proteomics, senescence

Yubo Liu
contact affiliation	Dalian University of Technology
contact email	liuyubo@dlut.edu.cn
lab head
Yubo Liu
contact affiliation	Dalian University of Technology
contact email	liuyubo@dlut.edu.cn
dataset submitter

iProX dataset URI