PXD063039-1

PXD063039 is an original dataset announced via ProteomeXchange.

Title	Proteomic Profiling of the Hippocampus in Lithium-Deficient 3xTg-AD Mice
Description	This proteomics experiment aimed to identify proteins whose abundance is altered by lithium deficiency in the context of Alzheimer's disease pathology in mice. Female homozygous 3xTg-AD mice were continuously fed either a lithium-deficient or a control diet from 6 to 15 months of age. At the end of the treatment period, mice (n=4 per group) were sacrificed, perfused transcardially with PBS, and their hippocampi were extracted for proteomic analysis.
HostingRepository	PRIDE
AnnounceDate	2025-06-09
AnnouncementXML	Submission_2025-06-09_08:25:26.239.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Liviu Aron
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-16 12:09:42	ID requested
⏵ 1	2025-06-09 08:25:26	announced

Dataset with its publication pending

submitter keyword: Hippocampus, Alzheimer's disease,Lithium, Lithium deficiency

Bruce A. Yankner
contact affiliation	Harvard Medical School, Department of Genetics, Boston 02115 MA, USA
contact email	liviu@hms.harvard.edu
lab head
Liviu Aron
contact affiliation	Harvard Medical School, Department of Genetics
contact email	liviu@hms.harvard.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/06/PXD063039

PRIDE project URI

• PRIDE
  1. PXD063039
     1. Label: PRIDE project
     2. Name: Proteomic Profiling of the Hippocampus in Lithium-Deficient 3xTg-AD Mice