PXD062707-2

PXD062707 is an original dataset announced via ProteomeXchange.

Title	Proteomic and Acetylome Alterations in Obesity-related Osteoarthritic Mouse Cartilage
Description	Male mice aged 4 weeks were housed under controlled conditions and assigned to either a normal diet or a high-fat diet for 16 weeks to establish an obesity model. At 12 weeks, osteoarthritis was induced using the destabilization of the medial meniscus procedure under anesthesia, while sham-operated mice served as controls. Eight weeks post-surgery, tibial cartilage tissues were collected, ensuring surrounding tissues were removed under a microscope. Tissues from 3-5 mice per group were pooled, and flash-frozen for subsequent lipidomic, proteomic, and acetylome analyses.
HostingRepository	iProX
AnnounceDate	2025-04-08
AnnouncementXML	Submission_2025-07-06_20:46:31.014.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Shuying Shen
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	acetylated residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-04-08 00:16:54	ID requested
1	2025-04-08 00:17:09	announced
⏵ 2	2025-07-06 20:46:31	announced	2025-07-07: Add info.

Mei Z, Yilamu K, Ni W, Shen P, Pan N, Chen H, Su Y, Guo L, Sun Q, Li Z, Huang D, Fang X, Fan S, Zhang H, Shen S, Chondrocyte fatty acid oxidation drives osteoarthritis via SOX9 degradation and epigenetic regulation. Nat Commun, 16(1):4892(2025) [pubmed]

submitter keyword: Proteomic, Acetylome

Shunwu Fan
contact affiliation	Sir Run Run Shaw Hospital, Zhejiang University School of Medicin
contact email	shunwu_fan@zju.edu.cn
lab head
Shuying Shen
contact affiliation	Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
contact email	11207057@zju.edu.cn
dataset submitter

iProX dataset URI