PXD062532 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Detection of the TDP-43 interactome in C57Bl/6J mouse cortex and cerebellum using LC-MSMS |
| Description | TDP-43 is a primary pathogenic protein in both amyotrophic lateral sclerosis and frontotemporal dementia, but it’s accumulation and aggregation show regional variation, with abundant deposition in the cortex, and a much lower burden in the cerebellum. Here we use mass spectrometry analysis to compare the protein interactome of TDP-43 within the cortex and cerebellum of young healthy C57Bl/6J mice. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-01-16 |
| AnnouncementXML | Submission_2026-01-16_03:49:40.151.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD062532 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Steven Lynham |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-04-02 09:24:22 | ID requested | |
| ⏵ 1 | 2026-01-16 03:49:40 | announced | |
Publication List
Keyword List
| submitter keyword: Mouse, cerebellum, LC-MC/MS, cortex, TDP-43 |
Contact List
| Dr Jacqueline Mitchell |
|---|
| contact affiliation | Dept Basic and Clinical Neuroscience, Institute of Psychology, Psychiatry and Neuroscience, Kings College London |
| contact email | jacqueline.mitchell@kcl.ac.uk |
| lab head | |
| Steven Lynham |
|---|
| contact affiliation | King's College London |
| contact email | steven.lynham@kcl.ac.uk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD062532
- Label: PRIDE project
- Name: Detection of the TDP-43 interactome in C57Bl/6J mouse cortex and cerebellum using LC-MSMS
