PXD059578-2
PXD059578 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Chronic stress-induced cholesterol metabolism abnormalities promote ESCC tumorigenesis and predict neoadjuvant therapy response |
| Description | chronic stress activates the GCR-HMGB2-LDLR axis via cortisol release, leading to abnormal cholesterol metabolism and ultimately promoting esophageal carcinogenesis |
| HostingRepository | iProX |
| AnnounceDate | 2025-01-09 |
| AnnouncementXML | Submission_2025-08-14_23:35:44.762.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Ting Wang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | 4800 Plus MALDI TOF/TOF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-01-08 23:49:13 | ID requested | |
| 1 | 2025-01-08 23:49:29 | announced | |
| ⏵ 2 | 2025-08-14 23:35:45 | announced | 2025-08-15: Add info. |
Publication List
| Wang T, Wang X, Wang K, Yu M, Bai R, Zhang Y, Zhang Z, Liu F, Wang R, Shi X, Jia L, Liu K, Li X, Jin G, Zhao S, Dong Z, Chronic stress-induced cholesterol metabolism abnormalities promote ESCC tumorigenesis and predict neoadjuvant therapy response. Proc Natl Acad Sci U S A, 122(5):e2415042122(2025) [pubmed] |
Keyword List
| submitter keyword: ESCC,Chronic stress, Cortisol, GCR, HMGB2, LDLR, Cholesterol |
Contact List
| Zigang Dong | |
|---|---|
| contact affiliation | School of Basic Medical Sciences, Zhengzhou University |
| contact email | dongzg@zzu.edu.cn |
| lab head | |
| Ting Wang | |
| contact affiliation | School of Basic Medical Sciences, Zhengzhou University |
| contact email | twang@hci-cn.org |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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