PXD057978-2

PXD057978 is an original dataset announced via ProteomeXchange.

Title	Murine Leukemia Virus GlycoGag Antagonizes SERINC5 via the ER-phagy Receptor RETREG1
Description	Our findings thus far indicate that Ser5 and glycoGag can be detected in the ER, with glycoGag downregulating Ser5 intracellularly through lysosomal degradation. We hypothesized that glycoGag downregulation of Ser5 is mediated by ER-phagy. Thus, we employed affinity-purified MS to identify its specific ER-phagy receptor.
HostingRepository	iProX
AnnounceDate	2024-11-17
AnnouncementXML	Submission_2025-08-20_19:13:01.453.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sunan Li
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-17 22:04:35	ID requested
1	2024-11-17 22:05:01	announced
⏵ 2	2025-08-20 19:13:02	announced	2025-08-21: Add info.

Zheng YH, Li Q, Li S, Ye B, Liang J, ADAM17 is an HIV-1 Restriction Factor Antagonized by Nef. Res Sq, ():(2025) [pubmed]

submitter keyword: MS results of Ser5, glycoGag, Ser5+glycoGag, Nef, and Nef+Ser5both with a C-terminal HA tag (glycoGag-HA, Nef-HA)

Sunan Li
contact affiliation	Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences (CAAS)
contact email	lisunan@caas.cn
lab head
Sunan Li
contact affiliation	Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences (CAAS)
contact email	lisunan@caas.cn
dataset submitter

iProX dataset URI