PXD057010-1

PXD057010 is an original dataset announced via ProteomeXchange.

Title	Ancient DNA and protein preservation and transfer in concretions covering human remains
Description	Archaeological remains covered with concretions, including human bones, are commonly found in certain areas and time periods of interest for understanding the past, but have yet to be investigated for potential ancient DNA (aDNA) and protein content. We extracted aDNA and proteins in tandem from human dental remains and the concretions surrounding them and compared them to non-concreted human dental remains from the same site. Concretions appeared homogeneous in colour and texture, consisting of a hard dark grey sediment adhered to the bone surfaces, presumably as a result of cyclical waterlogging of the burial deposits as well as postcranial human remains from a contemporary site. Concretions were found to contain human oral microbiome genomic and proteomic leached from the original skeletal source, as well as environmental and human proteins. Despite this, both the original element and concretions lacked endogenous human aDNA, indicating that the use of this type of material in future molecular archaeological applications is limited.
HostingRepository	PRIDE
AnnounceDate	2025-07-16
AnnouncementXML	Submission_2025-07-16_12:59:40.744.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rémi Barbieri
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	(R)-5-oxo-1; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-21 06:15:23	ID requested
⏵ 1	2025-07-16 12:59:41	announced

Dataset with its publication pending

submitter keyword: preservation, oral microbiota,biomolecules, adna, concretion, metaproteomics

Christiana Lyn
contact affiliation	1. Estonian Biocentre, Institute of Genomics, University of Tartu, Riia 23B, Tartu, 51010, Estonia 2. Department of Zoology, University of Cambridge, CB2 3EJ, United Kingdom 3. St John’s College, University of Cambridge, CB2 1TP, United Kingdom
contact email	cls83@cam.ac.uk
lab head
Rémi Barbieri
contact affiliation	University of Tartu
contact email	remibarbieri@hotmail.fr
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD057010
     1. Label: PRIDE project
     2. Name: Ancient DNA and protein preservation and transfer in concretions covering human remains