PXD056761 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteome profiling of virulence-associated CipC from Cryptococcus neoformans |
Description | Cryptococcus neoformans is a human fungal pathogen found ubiquitously within the environment and associated with infection of primarily immunocompromised individuals. Without the activation of an effective immune response, the pathogen can survive, proliferate, and disseminate throughout the host through the action of diverse virulence factors. These virulence factors include a polysaccharide capsule to protect the fungus from phagocytosis by macrophages, melanin production to neutralize reactive oxygen species, thermotolerance to survive at human physiological temperatures, and extracellular enzymes for host tissue degradation and invasion. We previously used mass spectrometry-based proteomics to explore the production of fungal virulence factors during infection using in vitro (macrophages) and in vivo (murine) models of disease. Based on our studies, we investigated the proteome response of C. neoformans upon disruption of CipC, a virulence-associated fungal protein. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_07:01:30.578.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jennifer Geddes-McAlister |
SpeciesList | scientific name: Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii); NCBI TaxID: 235443; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Exploris 240 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-10-13 11:58:52 | ID requested | |
1 | 2024-10-13 12:07:09 | announced | |
⏵ 2 | 2024-10-22 07:01:30 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: fungal virulence, Cryptococcus neoformans,Total proteome |
Contact List
Jennifer Geddes-McAlister |
contact affiliation | Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada |
contact email | jgeddesm@uoguelph.ca |
lab head | |
Jennifer Geddes-McAlister |
contact affiliation | University of Guelph |
contact email | jgeddesm@uoguelph.ca |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD056761 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD056761
- Label: PRIDE project
- Name: Proteome profiling of virulence-associated CipC from Cryptococcus neoformans