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PXD056761-1

PXD056761 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteome profiling of virulence-associated CipC from Cryptococcus neoformans
DescriptionCryptococcus neoformans is a human fungal pathogen found ubiquitously within the environment and associated with infection of primarily immunocompromised individuals. Without the activation of an effective immune response, the pathogen can survive, proliferate, and disseminate throughout the host through the action of diverse virulence factors. These virulence factors include a polysaccharide capsule to protect the fungus from phagocytosis by macrophages, melanin production to neutralize reactive oxygen species, thermotolerance to survive at human physiological temperatures, and extracellular enzymes for host tissue degradation and invasion. We previously used mass spectrometry-based proteomics to explore the production of fungal virulence factors during infection using in vitro (macrophages) and in vivo (murine) models of disease. Based on our studies, we investigated the proteome response of C. neoformans upon disruption of CipC, a virulence-associated fungal protein.
HostingRepositoryPRIDE
AnnounceDate2024-10-13
AnnouncementXMLSubmission_2024-10-13_12:07:09.023.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJennifer Geddes-McAlister
SpeciesList scientific name: Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii); NCBI TaxID: 235443;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Exploris 240
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-10-13 11:58:52ID requested
12024-10-13 12:07:09announced
22024-10-22 07:01:30announced2024-10-22: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: fungal virulence, Cryptococcus neoformans,Total proteome
Contact List
Jennifer Geddes-McAlister
contact affiliationDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada
contact emailjgeddesm@uoguelph.ca
lab head
Jennifer Geddes-McAlister
contact affiliationUniversity of Guelph
contact emailjgeddesm@uoguelph.ca
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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