PXD056504-1

PXD056504 is an original dataset announced via ProteomeXchange.

Title	Discovery of Trypanosoma brucei inhibitors enabled by a unified synthesis of diverse sulfonyl fluorides
Description	A unified synthesis of skeletally-diverse sulfonyl fluorides was developed that relied upon photoredox-catalysed dehydrogenative couplings between hetaryl sulfonyl fluorides and hydrogen donor building blocks. A set of 32 diverse probes were prepared, and then screened against Trypanosoma brucei. Four of the probes were found to have sub-micromolar anti-trypanosomal activity. A chemical proteomic approach, harnessing an alkynylated analogue and broad-spectrum fluorophosphonate tools, provided insights into the observed anti-trypanosomal activity, which likely stems from covalent modification of multiple protein targets.
HostingRepository	PRIDE
AnnounceDate	2024-10-17
AnnouncementXML	Submission_2024-10-17_02:12:03.334.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Brian Suarez-Mantilla
SpeciesList	scientific name: Trypanosoma brucei; NCBI TaxID: 5691;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro 2

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-04 07:36:44	ID requested
⏵ 1	2024-10-17 02:12:03	announced

10.1038/S42004-024-01327-8;

submitter keyword: Medicinal chemistry, photoredox chemistry, Chemoproteomics, Sulfonyl fluoride

Adam Nelson
contact affiliation	Professor of Chemical Biology School of Chemistry University of Leeds LS2 9JT
contact email	a.s.nelson@leeds.ac.uk
lab head
Brian Suarez-Mantilla
contact affiliation	School of Chemistry, University of Leeds
contact email	B.A.SuarezMantilla@leeds.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD056504

PRIDE project URI

• PRIDE
  1. PXD056504
     1. Label: PRIDE project
     2. Name: Discovery of Trypanosoma brucei inhibitors enabled by a unified synthesis of diverse sulfonyl fluorides