PXD056270-1

PXD056270 is an original dataset announced via ProteomeXchange.

Title	Migrions, a Migrasome-mediated unit for Intercellular Viral Transmission
Description	Efficient intercellular virus spread significantly contributes to overall pathogenesis and virulence. Our study reveals that viral RNAs and proteins are transported to migrasomes during cell migration. This chimera of migrasomes and virions, termed Migrion, demonstrates infectivity, resulting in greater infection efficiency compared to free virus particles. Moreover, the clustered packaging of viral components by Migrion facilitated the collective transfer and replication of multiple viral nucleic acids within single recipient cells. Mechanistically, endocytosis, endosomal acidification and content release is essential for Migrion infection. Migrion represents a novel mode of viral transmission among cells, which couples viral transmission with cell migration, adding another piece to the puzzle of viral spreading mechanisms.
HostingRepository	iProX
AnnounceDate	2024-09-25
AnnouncementXML	Submission_2024-09-25_20:16:18.582.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Haohao Tang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-09-25 20:15:36	ID requested
⏵ 1	2024-09-25 20:16:19	announced

Dataset with its publication pending

submitter keyword: Migrions,Intercellular Viral Transmission

Yang Chen
contact affiliation	Peking University Health Science Center
contact email	chenyang1816185048@bjmu.edu.cn
lab head
Haohao Tang
contact affiliation	Peking University Health Science Center
contact email	Tanghaohao0987@163.com
dataset submitter

iProX dataset URI