Efficient intercellular virus spread significantly contributes to overall pathogenesis and virulence. Our study reveals that viral RNAs and proteins are transported to migrasomes during cell migration. This chimera of migrasomes and virions, termed Migrion, demonstrates infectivity, resulting in greater infection efficiency compared to free virus particles. Moreover, the clustered packaging of viral components by Migrion facilitated the collective transfer and replication of multiple viral nucleic acids within single recipient cells. Mechanistically, endocytosis, endosomal acidification and content release is essential for Migrion infection. Migrion represents a novel mode of viral transmission among cells, which couples viral transmission with cell migration, adding another piece to the puzzle of viral spreading mechanisms.