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PXD054129-1

PXD054129 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomics reveals the mechanism of Qingre Huo xue decoction in treating rheumatoid arthritis
DescriptionRheumatoid arthritis is an autoimmune disease characterized by chronic synovitis, which can lead to irreversible joint damage as well as cardiovascular and respiratory system damage. The Qingre Huoxue Decoction is a Chinese medicine compound that has been clinically proven to be effective in treating RA, but its mechanism has not yet been elucidated. This study identified 83 differentially expressed proteins, including 46 upregulated proteins and 37 downregulated proteins, through proteomic analysis of the serum of RA patients before and after 24 weeks of treatment with Qingre Huoxue Decoction and healthy human. Among them, FBP1 protein may be a potential therapeutic target of Qingre Huoxue Decoction.
HostingRepositoryiProX
AnnounceDate2024-07-23
AnnouncementXMLSubmission_2024-07-22_20:43:40.953.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterFuyuan Zhang
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-07-22 20:41:25ID requested
12024-07-22 20:43:41announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Rheumatoid arthritis, Chinese Medicine, DIA proteomics, LC-MS/MS, Fructose-1,6-bisphosphatase
Contact List
Jiang Quan
contact affiliationGuang'anmen Hospital of the Chinese Academy of Traditional Chinese Medicine
contact emaildoctorjq@126.com
lab head
Fuyuan Zhang
contact affiliationGuang'anmen Hospital of the Chinese Academy of Traditional Chinese Medicine
contact emaildoctorzfy@126.com
dataset submitter
Full Dataset Link List
iProX dataset URI