PXD054129-1

PXD054129 is an original dataset announced via ProteomeXchange.

Title	Proteomics reveals the mechanism of Qingre Huo xue decoction in treating rheumatoid arthritis
Description	Rheumatoid arthritis is an autoimmune disease characterized by chronic synovitis, which can lead to irreversible joint damage as well as cardiovascular and respiratory system damage. The Qingre Huoxue Decoction is a Chinese medicine compound that has been clinically proven to be effective in treating RA, but its mechanism has not yet been elucidated. This study identified 83 differentially expressed proteins, including 46 upregulated proteins and 37 downregulated proteins, through proteomic analysis of the serum of RA patients before and after 24 weeks of treatment with Qingre Huoxue Decoction and healthy human. Among them, FBP1 protein may be a potential therapeutic target of Qingre Huoxue Decoction.
HostingRepository	iProX
AnnounceDate	2024-07-23
AnnouncementXML	Submission_2024-07-22_20:43:40.953.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Fuyuan Zhang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-22 20:41:25	ID requested
⏵ 1	2024-07-22 20:43:41	announced

Dataset with its publication pending

submitter keyword: Rheumatoid arthritis, Chinese Medicine, DIA proteomics, LC-MS/MS, Fructose-1,6-bisphosphatase

Jiang Quan
contact affiliation	Guang'anmen Hospital of the Chinese Academy of Traditional Chinese Medicine
contact email	doctorjq@126.com
lab head
Fuyuan Zhang
contact affiliation	Guang'anmen Hospital of the Chinese Academy of Traditional Chinese Medicine
contact email	doctorzfy@126.com
dataset submitter

iProX dataset URI