PXD053688-2

PXD053688 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of bone marrow-derived macrophages after Nano-IFNγ/Zole and GGPP incubation
Description	We designed and prepared a bisphosphonate-mineralized Nano-IFNγ (Nano-IFNγ/Zole) to promote trans-differentiation of macrophages from the M2 to M1 type. Bisphosphonate in the Nano-IFNγ/Zole reduced lysosomal acidification by inhibiting isoprene modification of Rab family proteins, enhanced tumor antigen cross-presentation and activated the TFEB pathway. These mechanisms, in conjunction with IFNγ-activated JAK/STAT1 signaling, facilitated the trans-differentiation of macrophages.
HostingRepository	iProX
AnnounceDate	2024-07-05
AnnouncementXML	Submission_2025-12-09_17:59:38.317.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhicheng Yan
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-05 02:55:04	ID requested
1	2024-07-05 02:55:43	announced
⏵ 2	2025-12-09 17:59:39	announced	2025-12-10: Add info

Yan Z, Wang B, Shen Y, Ren J, Chen M, Jiang Y, Wu H, Dai W, Zhang H, Wang X, Zhang Q, Yang W, He B, suppresses residual tumor growth caused by incomplete radiofrequency ablation through metabolically remodeling tumor-associated macrophages. Theranostics, 15(3):1057-1076(2025) [pubmed]

submitter keyword: bone marrow-derived macrophages, bisphosphonates, mevalonate metabolic pathway, interferon-γ

Qiang Zhang
contact affiliation	Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University
contact email	zqdodo@bjmu.edu.cn
lab head
Zhicheng Yan
contact affiliation	Peking University
contact email	yanzhicheng_0908@163.com
dataset submitter

iProX dataset URI