PXD053688-1

PXD053688 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of bone marrow-derived macrophages after Nano-IFNγ/Zole and GGPP incubation
Description	We designed and prepared a bisphosphonate-mineralized Nano-IFNγ (Nano-IFNγ/Zole) to promote trans-differentiation of macrophages from the M2 to M1 type. Bisphosphonate in the Nano-IFNγ/Zole reduced lysosomal acidification by inhibiting isoprene modification of Rab family proteins, enhanced tumor antigen cross-presentation and activated the TFEB pathway. These mechanisms, in conjunction with IFNγ-activated JAK/STAT1 signaling, facilitated the trans-differentiation of macrophages.
HostingRepository	iProX
AnnounceDate	2024-07-05
AnnouncementXML	Submission_2024-07-05_02:55:43.299.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhicheng Yan
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-05 02:55:04	ID requested
⏵ 1	2024-07-05 02:55:43	announced

Dataset with its publication pending

submitter keyword: bone marrow-derived macrophages, bisphosphonates, mevalonate metabolic pathway, interferon-γ

Qiang Zhang
contact affiliation	Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University
contact email	zqdodo@bjmu.edu.cn
lab head
Zhicheng Yan
contact affiliation	Peking University
contact email	yanzhicheng_0908@163.com
dataset submitter

iProX dataset URI