PXD052711-1

PXD052711 is an original dataset announced via ProteomeXchange.

Title	Neutrophil proteome of severe malaria adult patients in Mozambique
Description	Malaria is a truly devastating global disease, with over 240 million infections and over 600,000 deaths reported annually worldwide, with deaths occurring mainly in children under 5 years old. Malaria is caused by infection with the Plasmodium parasite, which infects erythrocytes and promotes sequestration to the vascular endothelium, leading to vascular occlusion and increased permeability, inflammation and anemia due to the rupturing of infected red blood cells. The role of neutrophils in malaria still remains to be fully understood. Previous work by our laboratory has demonstrated neutrophil extracellular traps (NETs), extruded webs of decondensed chromatin decorated with granule proteins, enhances interactions between parasite-infected red blood cells and the vascular endothelium, promoting organ damage. We hypothesized that malaria induces developmental changes in neutrophils that affect their functional responses and therefore wanted to characterise the proteome of neutrophils from adult patients infected with plasmodium falciparum.
HostingRepository	PRIDE
AnnounceDate	2026-09-07
AnnouncementXML	Submission_2026-09-06_16:31:47.134.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Borko Amulic
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2024-05-30 06:06:58	ID requested
⏵ 1	2026-09-06 16:31:48	announced

Zakrzewski P, Rice CM, Naveh C, Dowell I, Fleming K, Ramesh AV, Jones R, Moura PL, Cela D, Groves S, Fletcher-Jones S, Victory Y, Bhima M, Ebmeier S, Carey L, Butler M, Satchell SC, Berg A, Palolite N, Nyirenda J, Nyasulu W, Zgambo I, Attipa C, Wooldridge L, Davidson AD, Cunnington A, Moxon CA, Amulic B, Mitochondrial activity promotes neutrophil degranulation and endothelial dysfunction in systemic infections. EMBO Mol Med, 18(7):2691-2722(2026) [pubmed]

10.1038/s44321-026-00453-1;

submitter keyword: Malaria, neutrophil

Borko Amulic
contact affiliation	University of Bristol, UK
contact email	borko.amulic@bristol.ac.uk
lab head
Borko Amulic
contact affiliation	University of Bristol
contact email	borko.amulic@bristol.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD052711

PRIDE project URI

• PRIDE
  1. PXD052711
     1. Label: PRIDE project
     2. Name: Neutrophil proteome of severe malaria adult patients in Mozambique