Malaria is a truly devastating global disease, with over 240 million infections and over 600,000 deaths reported annually worldwide, with deaths occurring mainly in children under 5 years old. Malaria is caused by infection with the Plasmodium parasite, which infects erythrocytes and promotes sequestration to the vascular endothelium, leading to vascular occlusion and increased permeability, inflammation and anemia due to the rupturing of infected red blood cells. The role of neutrophils in malaria still remains to be fully understood. Previous work by our laboratory has demonstrated neutrophil extracellular traps (NETs), extruded webs of decondensed chromatin decorated with granule proteins, enhances interactions between parasite-infected red blood cells and the vascular endothelium, promoting organ damage. We hypothesized that malaria induces developmental changes in neutrophils that affect their functional responses and therefore wanted to characterise the proteome of neutrophils from adult patients infected with plasmodium falciparum.