PXD050688 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Identification of interacting proteins with U4 snRNA with and without USP39 |
| Description | RNA splicing and protein degradation systems allow the functional adaptation of the proteome in response to changing cellular contexts. However, the regulatory mechanisms connecting these processes remain poorly understood. Here, we show that impaired spliceosome assembly caused by USP39 deficiency leads to a pathogenic splicing profile characterized by the use of cryptic 5′ splice sites. We performed MS analysis to identify the main interactors of U4 snRNA with and without USP39 |
| HostingRepository | PRIDE |
| AnnounceDate | 2024-10-22 |
| AnnouncementXML | Submission_2024-10-22_06:59:42.232.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD050688 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Alfredo Cabrera-Orefice |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-03-16 21:38:01 | ID requested | |
| 1 | 2024-09-25 08:59:03 | announced | |
| ⏵ 2 | 2024-10-22 06:59:42 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
| submitter keyword: Human, U4 snRNA, spliceosome, USP39, AS oligo pulldown |
Contact List
| Alfredo Cabrera-Orefice |
|---|
| contact affiliation | Functional Proteomics Center, Institute for Cardiovascular Physiology, Goethe University Frankfurt, Frankfurt am Main, Germany. |
| contact email | alfredbiomed@gmail.com |
| lab head | |
| Alfredo Cabrera-Orefice |
|---|
| contact affiliation | Goethe University Frankfurt |
| contact email | alfredbiomed@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/09/PXD050688 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD050688
- Label: PRIDE project
- Name: Identification of interacting proteins with U4 snRNA with and without USP39
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