PXD050688-1

PXD050688 is an original dataset announced via ProteomeXchange.

Title	Identification of interacting proteins with U4 snRNA with and without USP39
Description	RNA splicing and protein degradation systems allow the functional adaptation of the proteome in response to changing cellular contexts. However, the regulatory mechanisms connecting these processes remain poorly understood. Here, we show that impaired spliceosome assembly caused by USP39 deficiency leads to a pathogenic splicing profile characterized by the use of cryptic 5′ splice sites. We performed MS analysis to identify the main interactors of U4 snRNA with and without USP39
HostingRepository	PRIDE
AnnounceDate	2024-09-25
AnnouncementXML	Submission_2024-09-25_08:59:03.309.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD050688
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Alfredo Cabrera-Orefice
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-16 21:38:01	ID requested
⏵ 1	2024-09-25 08:59:03	announced
2	2024-10-22 06:59:42	announced	2024-10-22: Updated project metadata.

10.6019/PXD050688;

submitter keyword: Human, U4 snRNA, spliceosome, USP39, AS oligo pulldown

Alfredo Cabrera-Orefice
contact affiliation	Functional Proteomics Center, Institute for Cardiovascular Physiology, Goethe University Frankfurt, Frankfurt am Main, Germany.
contact email	alfredbiomed@gmail.com
lab head
Alfredo Cabrera-Orefice
contact affiliation	Goethe University Frankfurt
contact email	alfredbiomed@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD050688
     1. Label: PRIDE project
     2. Name: Identification of interacting proteins with U4 snRNA with and without USP39