PXD050317 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteome dynamics of HL-60, NB4, and K562 cells under the ATRA treatment |
Description | Searching for new strategies of acute myeloid leukemia (AML) treatment is of particular interest. Cell lines, e. g. HL-60 and NB4, represent model systems to study molecular features of leukemic cells. The all-trans-retinoic acid (ATRA) has proven itself to be an effective treatment for one of AML subtypes, i.e., acute promyelocytic leukemia (APL). At the same time, ATRA causes granulocytic differentiation of non-APL leukemic cells in vitro. Combination of new therapeutics with ATRA could improve efficiency of treatment. Studying the proteome perturbation in leukemic cells under the ATRA treatment allows to determine potential regulatory molecules that could be affected pharmacologically. Thus, the TMT-based proteomic profiles of HL-60, NB4, and K562 cell lines under the ATRA treatment were obtained at 0, 3, 12, 24, and 72 h after the ATRA treatment. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_06:47:05.619.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Svetlana Novikova |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-03-04 02:53:54 | ID requested | |
1 | 2024-06-23 01:49:54 | announced | |
⏵ 2 | 2024-10-22 06:47:06 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.3390/ijms25094618; |
Novikova S, Tolstova T, Kurbatov L, Farafonova T, Tikhonova O, Soloveva N, Rusanov A, Zgoda V, Systems Biology for Drug Target Discovery in Acute Myeloid Leukemia. Int J Mol Sci, 25(9):(2024) [pubmed] |
Keyword List
submitter keyword: NB4 cell line, K562 cell line, ATRA, TMT labeling, time-course experiment,HL-60 cell line, proteome |
Contact List
Victor Zgoda |
contact affiliation | Laboratory of Systems Biology,Institute of Biomedical Chemistry, Moscow, Russia |
contact email | victor.zgoda@gmail.com |
lab head | |
Svetlana Novikova |
contact affiliation | Institute of Biomedical Bhemistry (IBMC), Moscow |
contact email | novikova.s.e3101@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD050317
- Label: PRIDE project
- Name: Proteome dynamics of HL-60, NB4, and K562 cells under the ATRA treatment